项目名称： 宽波长纳米金载药系统的制备及其组装机制和光响应研究

项目编号： No.21476190

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 有机化学

项目作者： 高大威

作者单位： 燕山大学

项目金额： 90万元

中文摘要： 目前光控药物传递系统仍存在体内释药延迟、深部组织无响应、不能按需释药和批量合成困难等问题。本项目旨在通过控制合成宽波长的纳米金球壳载药系统，大幅度提高纳米金载药系统在深部组织的光响应性和瞬间释药能力。重点研究其中的核心科学问题- - 宽波长等离子共振峰纳米金载药系统的制备及其机制和深部组织光响应规律，通过调控纳米金粒子在脂质体表面的排布、纳米金粒径和间距等，制备出超薄纳米金球壳包覆的载药系统，实现在组织深部由纳米金控制的药物按需释放。采用琼脂糖凝胶光控释药检测技术研究不同波长纳米金载体对应的光响应深度，阐明光辐射条件对纳米金载药系统释药量的控制规律，以及光辐射波长与载药系统响应深度的量效关系，并探讨规模化制备该载药系统的合成规律。有关800-1000 nm波长的纳米金载药脂质体对应组织光控响应深度的研究未见文献报道，此研究结果将为药物传递系统的规模化合成和应用提供重要的基础数据和理论依据。

中文关键词： 共振峰波长；纳米金粒子；药物传递系统；光热转换；控制释放

英文摘要： At present, there are still some unsolved problems in the field of optically controlled drug delivery system, including time delay of drug release in vivo, no response for deep tissue, great difficulty to achieve on-demand drug release and batch perparation. In this project, liposome encapsulated Au nanoparticles with a wide wavelength region for surface plasmon resonance will be developed to improve vastly the abilities of photoresponse and instantaneous release in deep tissue. As the core scientific issues of this project, synthesis mechanisms of the drug delivery system and its response regularity to optical radiation will be explored in depth. Meanwhile, several factors are regarded as the extremely important things to regulate the properties of this novel drug delivery system, such as distribution of gold nanoparticles on the surface of liposomes, partical size and gap between gold nanoparticles. In order to measure photoresponse depth of nanogold shell liposomes with different surface plasmon resonance peaks, agarose-gel photo-controlled drug release detection technology will be applied, which can illistrate dose-effect relationship between light wavelength and response depth of drug delivery system and reveal the fundamental controlling rules of the system's drug release quantity under different optical radiation conditions. In addition, the synthesis rules of the nanogold coated liposomes for large-scale preparation will be explored. To our knowledge, by far, there is no related research report on response depth of drug delivery system with 800-1000 nm resonance peak to outside photoexcitation. Our results will supply pivotal basic data and theoretical foundation for drug delivery system's large-scale preparation and widespread application.

英文关键词： resonance peak wavelength;gold nanoparticles;drug delivery system;photothermal conversion;controlled release