项目名称： 基于柱芳烃的高分子药物输送载体

项目编号： No.51503042

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 一般工业技术

项目作者： 马达

作者单位： 复旦大学

项目金额： 20万元

中文摘要： 申请人计划利用最新一代、容易制备的主体大环分子柱芳烃，以柱芳烃衍生物为聚合单体形成高分子或者直接修饰高分子，得到新型柱芳烃高分子材料。我们将研究柱芳烃高分子材料与小分子和大分子药物的相互作用，诠释其载药与释药规律。并且利用柱芳烃高分子材料，通过共价交联或者主客体交联的办法，组装纳米粒子。我们将利用调节柱芳烃与小分子独特的主客体作用，调控柱芳烃高分子材料的药物输送行为。同时，加入靶向官能团，实现靶向给药。在系统研究其生物兼容性以后，我们将研究其细胞层面的药物输送效果，并且研究体内所输送药物的各器官分布与对癌组织的递药效果。

中文关键词： 药物载体；主客体化学；高分子材料；纳米颗粒

英文摘要： The applicant plans to use the newest generation of macrocyclic host pillar[n]arene. By using pillar[n]arene derivatives as macromers to form polymers or using them to graft polymers, we will get novel pillar[n]arene based polymeric materials. By investigating the interaction between pillar[n]arene based polymeric materials and small molecule or large molecule drugs, we will try to find the basic rule for its drug loading and drug releasing. We will also use pillarene based polymeric materials to assemble nanoparticles by covalent or host-guest cross-linking. By adjusting the host-guest chemistry of pillar[n]arene and small molecules, we are able to control the drug delivery behavior of pillar[n]arene based polymeric materials. By introducing targeting groups, we can also realize target specific drug delivery. After studying its biocompatibility, we will study its drug delivery to cells, biodistribution in vivo, and drug delivery effect to cancer tissues.

英文关键词： Drug Carriers;Host-guest Chemistry;Polymeric Materials;Nanoparticles