项目名称： 基于金纳米棒的高性能微纳传感阵列的结构设计和机理研究

项目编号： No.61501320

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 无线电电子学、电信技术

项目作者： 王艳艳

作者单位： 天津大学

项目金额： 23万元

中文摘要： 金纳米棒具有独特的局域表面等离子共振性质，将不同尺寸的金纳米棒作为传感元件可构建微型化的传感器，而金纳米棒的有序排列可使其等离子共振相互叠加，最大化地激发金纳米棒的整体性能，数量级提高检测灵敏度。但目前基于金纳米棒的传感器阵列构建还面临着金纳米棒排列可控性不足和机理不明确的问题。本项目将以微纳加工与纳米棒自组装技术相结合，设计可控有序排列的金纳米棒微纳传感阵列；并系统探讨物理化学因素对组装阵列可控性和等离子共振耦合效应的影响，揭示耦合效应的具体机制；最后将所构建的高性能微纳传感阵列应用于医疗中多重肿瘤标志物的检测，对本项目的技术和理论进行实证。本项目的研究有望整体提升微纳传感技术的检测性能，提供一种新型的高灵敏度、高准确率检测生物大分子的方法，并可广泛适用于其它生物、化学分子和细胞等分析物的检测中。

中文关键词： 微纳米传感器原理；金纳米棒；微阵列；局域表面等离子共振；生物分子检测

英文摘要： Au Nanorod (AuNR) possesses special localized surface plasmon resonance (LSPR) property. Its LSPR band can be tuned by varying aspect ratio of AuNR, which makes AuNR a potential candidate for miniaturized sensor transducer. Additionally, by controlling the AuNRs arrangement, their LSPR can be coupled, resulting in enhancement of detection performance in order of magnitude. But how to controllable building orderly nanorods array and finding out their coupling mechanism are still key issues for fabricating high performance AuNRs sensor array. In this proposal, we propose to design a kind of controllable orientation AuNRs nano/micro array by combined micro-fabrication and self-assembly methods. Systematically studying how the physical and chemical conditions influence the array arrangement and plasmonic coupling, discovering the specific mechanism of LSPR coupling, to realize the enhancement of detection performance. Finally, we will utilize this fabricated sensor to detect cancer biomarker for early stage cancer diagnosis. The finding and insight of this proposal can aid in the enhancement of detection performance, provide a new molecular detection method, and will extend its application to high sensitivity detection of (bio)molecules and cells.

英文关键词： Principle of micro/nano sensor;Au nanorod;Microarray;Localized surface plasmon resonance;Biomolecular detection