项目名称： 折射率显微镜技术及其应用研究

项目编号： No.61475078

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 叶青

作者单位： 南开大学

项目金额： 80万元

中文摘要： 折射率是表征物质光学性质的基本物理量之一。在疾病诊断、光信息器件制备等方面对折射率分布测量的需求越来越大，且其准确测量的很多问题亟待解决。本项目提出一种高分辨测量折射率分布的全新技术-折射率显微成像技术。拟通过实验测量与计算模拟相结合的方式，开展折射率显微的原理、技术及其应用等研究。对生物组织和光信息器件进行折射率显微成像研究，开展粗糙表面效应和浑浊介质光散射对准确测定折射率分布影响的研究，其研究结果对疾病早期诊断、光信息器件的制备等方面有重要的意义。拟开展的主要工作：提出聚焦全内反射法和显微全内反射法，并应用此方法组建折射率显微镜，研究提高其空间分辨率和测量速度的方法；分别采用实验和模拟研究的方法，得到粗糙表面效应和浑浊介质光散射对折射率影响的具体关系，提出和实现去除粗糙表面效应的方法；开展折射率分布与疾病诊断之间关系的研究；开展光波导器件、光致折射率变化器件的折射率显微成像研究。

中文关键词： 折射率显微；全内反射；生物组织；表面粗糙度

英文摘要： Refractive index(RI) is one of the basic optical parameters of materials. In the area of diagnosis of disease and manufacture of optical information devices, the requirement for information of refractive index distribution is growing for a lot of problems of precisely measurement requir the RI information . This project offers a new technology to measure the refractive index distribution with high resolution- - refractive index microscopy. The theory, technology and appliance of refractive index microscopy through experimental measurements and theoretical simulations are investigated. We make an intensive study of RI distribution measurements on biological tissues and optical information devices. The influence of rough surface effect and the turbid medium light scattering on precisely measurement of the RI distribution are discussed. The results of this research play an important role in early diagnosis of disease and preparation of optical information devices. In this project, first, we provide focused total internal reflection method and total internal reflection microscopy, and then apply this method to set up the refractive index microscope. Experiments are carried on to improve the spatial resolution and the speed of the microscope. Secondly, we investigate the influence of rough surface effect and the turbid medium light scattering effect on RI distribution; and propose an effective way to decrease the rough surface effect. Finally, we carry out the relative research on the relationship between the RI distribution and diagnosis of disease. Research are also carried on other optical fields concerning RI distribution, such as refractive index photomicrographic on optical waveguide devices, and laser induced refractive index changes in devices.

英文关键词： refractive index microscopy;total internal reflection;biotissue;surface roughness