In recent years, the growing demand for medical imaging diagnosis has brought a significant burden to radiologists. The existing Med-VLP methods provide a solution for automated medical image analysis which learns universal representations from large-scale medical images and reports and benefits downstream tasks without requiring fine-grained annotations. However, the existing methods based on joint image-text reconstruction neglect the importance of cross-modal alignment in conjunction with joint reconstruction, resulting in inadequate cross-modal interaction. In this paper, we propose a unified Med-VLP framework based on Multi-task Paired Masking with Alignment (MPMA) to integrate the cross-modal alignment task into the joint image-text reconstruction framework to achieve more comprehensive cross-modal interaction, while a global and local alignment (GLA) module is designed to assist self-supervised paradigm in obtaining semantic representations with rich domain knowledge. To achieve more comprehensive cross-modal fusion, we also propose a Memory-Augmented Cross-Modal Fusion (MA-CMF) module to fully integrate visual features to assist in the process of report reconstruction. Experimental results show that our approach outperforms previous methods over all downstream tasks, including uni-modal, cross-modal and multi-modal tasks.

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