We consider the question of designing a universal family of sets $F \subset 2^{[n]}$ such that for any function $f:2^{[n]} \to R_{\geq 0}$ in a certain class, we have $$\max_{S \in F} f(S) \geq c(n) \cdot \max_{S \subset [n]} f(S).$$ We prove that there is a family of subpolynomial size such that for any nonnegative submodular function, $c(n) = Ω(\frac{\log \log n}{\log n})$, and there is a family of logarithmic size such that $c(n) = Ω(\frac{1}{\log n})$. We also prove that pairwise independence (which achieves a constant factor for graph cut functions), or even $k$-wise independence, does not imply a bound better than $O(\frac{1}{\sqrt{\log n}})$ for submodular functions. On the other hand, we prove that for any polynomially representable subclass of nonnegative submodular functions (such as the matroid connectivity functions for matroid representable over $F_q$), a constant-factor universal family of polynomial size always exists. For absolute XOS functions (a class that we introduce, in the form $f(S) = \max_i |\sum_{j \in S} w_{ij} + c_i|$ where $w_{ij}, c_i \in R$), we design a family of polynomial size such that $c(n) \geq \sqrt{\frac{\log n}{n}}$, and prove that there is no polynomial-size family achieving a factor better than $O(\sqrt{\frac{\log n}{n}})$.

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