Language is central to social communication, which is altered in autism, and language abilities vary widely among autistic individuals. How the autistic brain processes language is central to understanding autistic communication. Yet neuroimaging studies report inconsistent findings on how autistic brain activity is altered during language processing. We synthesized 45 fMRI and PET studies (753 autistic and 777 non-autistic participants) with seed-based d mapping with permutation of subject images (SDM-PSI). We estimated autistic and non-autistic activation and their difference with meta-regressions adjusted for each study's language modality and mean age. Autistic and non-autistic brains activated a similar left-lateralized language network. Autistic brains showed reduced activity throughout the left perisylvian cortex, from the inferior frontal gyrus to the mid superior temporal gyrus and the posterior superior temporal sulcus, and increased activity in the right temporal pole. Spoken language showed a larger autistic reduction than written language in the left mid superior temporal gyrus. Adults, but not children and adolescents, showed increased autistic activity in the right superior temporal gyrus and cuneus. Autistic language processing thus relies on the typical left-lateralized network but shows reduced leftward lateralization.

翻译：暂无翻译