Optimal encoding of classical data for quantum-assisted statistical inference is investigated from an information-theoretic perspective. We prove that the accuracy of any quantum-computing inference procedure is upper bounded by the maximal quantum leakage from the classical data through its quantum encoding, establishing leakage as a universal, task-agnostic quality measure for encoders. This demonstrates that the maximal quantum leakage is a universal measure of the quality of the encoding strategy for statistical inference as it only depends on the quantum encoding of the data and not the inference task itself. The optimal universal encoding strategy, i.e., an encoding strategy that maximizes the maximal quantum leakage, is proved to be attained by pure states. When there are enough qubits, basis encoding is proved to be universally optimal. However, when the dimension of the system is small, phase encoding is optimal. For the latter, any tight frame, any ensemble whose average state is the maximally mixed state, is in fact optimal. Within tight frames, equiangular tight frames (ETFs) are distinguished as the uniquely symmetric optimal encodings, i.e., they saturate the Welch lower bound on pairwise overlaps and possess a self-referential optimal measurement. Prominent special cases are the qubit trine, the regular simplex, and symmetric informationally complete positive operator-valued measures (SIC-POVMs), for which the ETF structure and explicit codeword constructions are provided. Numerical examples are presented to validate the theoretical predictions.

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