Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.

翻译：平台试验旨在评估多种治疗方案的疗效，允许试验组晚期进入，并通过共享对照组来提高效率。通过分析中利用非同期对照（NCC），可提升此类试验中个体治疗-对照比较的检验效能。本文介绍用于基于非同期对照的平台试验设计与分析的R包NCC。该软件包可模拟平台试验，并评估多种场景下利用非同期对照的分析方法特性。我们阐述了NCC的主要函数功能，并通过具体示例演示如何使用该软件包对平台试验进行模拟与分析。