We propose a continuous model for meniscus cartilage regeneration triggered by two populations of cells migrating and (de)differentiating within an artificial scaffold with a known structure. The described biological processes are influenced by a fluid flow and therewith induced deformations of the scaffold. Numerical simulations are done for the corresponding dynamics within a bioreactor which was designed for performing the biological experiments.
翻译:我们提出一个连续模型,用于描述在已知结构的人工支架内两类细胞迁移及(去)分化所触发的半月板软骨再生过程。所述生物过程受流体流动及由此引发的支架变形影响。针对生物反应器内相应动力学过程进行了数值模拟,该生物反应器专为实施生物学实验而设计。