Virtual Reality (VR) has emerged as a promising tool for enhancing social skills and emotional well-being in individuals with Autism Spectrum Disorder (ASD). Through a technical exploration, this study employs a multiplayer serious gaming environment within VR, engaging 34 individuals diagnosed with ASD and employing high-precision biosensors for a comprehensive view of the participants' arousal and responses during the VR sessions. Participants were subjected to a series of 3 virtual scenarios designed in collaboration with stakeholders and clinical experts to promote socio-cognitive skills and emotional regulation in a controlled and structured virtual environment. We combined the framework with wearable non-invasive sensors for bio-signal acquisition, focusing on the collection of heart rate variability, and respiratory patterns to monitor participants behaviors. Further, behavioral assessments were conducted using observation and semi-structured interviews, with the data analyzed in conjunction with physiological measures to identify correlations and explore digital-intervention efficacy. Preliminary analysis revealed significant correlations between physiological responses and behavioral outcomes, indicating the potential of physiological feedback to enhance VR-based interventions for ASD. The study demonstrated the feasibility of using real-time data to adapt virtual scenarios, suggesting a promising avenue to support personalized therapy. The integration of quantitative physiological feedback into digital platforms represents a forward step in the personalized intervention for ASD. By leveraging real-time data to adjust therapeutic content, this approach promises to enhance the efficacy and engagement of digital-based therapies.

翻译：虚拟现实（VR）已成为增强自闭症谱系障碍（ASD）患者社交技能和情绪健康的有效工具。通过技术探索，本研究采用VR中的多人严肃游戏环境，招募34名ASD患者，并使用高精度生物传感器全面监测参与者在VR会话中的唤醒状态与反应。参与者经历了一系列与利益相关者和临床专家合作设计的三个虚拟场景，旨在通过在受控结构化虚拟环境中提升社交认知技能和情绪调节能力。我们将该框架与用于生物信号采集的可穿戴非侵入式传感器相结合，重点收集心率变异性和呼吸模式数据以监测参与者行为。此外，通过观察和半结构化访谈进行行为评估，并将数据与生理指标联合分析，以识别相关性并探索数字干预的有效性。初步分析揭示了生理反应与行为结果之间的显著相关性，表明生理反馈在增强基于VR的ASD干预中的潜力。本研究证明了利用实时数据调整虚拟场景的可行性，为支持个性化治疗提供了有前景的途径。将定量生理反馈整合到数字平台中，标志着ASD个性化干预迈出了重要一步。通过利用实时数据调整治疗内容，该方法有望提升数字疗法的有效性和参与度。