This letter presents a mixed-precision CNN-LSTM accelerator for EEG-based sleep staging. To efficiently execute long temporal convolutions, a serpentine dataflow propagates activations between neighboring processing elements, reducing memory accesses by 6.2 times and 2.25 times compared with output- and weight-stationary dataflows, respectively. A hybrid quantization scheme applies runtime dynamic quantization to the LSTM and MLP layers and assigns mixed precision on a layer-by-layer basis, reducing model size by 4.16 times. Combined with a bit-flexible MAC architecture and channel-grouped memory scheduling, the accelerator supports INT2/4/8/16 inference. Fabricated in 65 nm CMOS, the accelerator consumes 0.40 mW and achieves a 258 times speedup over an iso-frequency 32b RISC-V processor. Evaluated across all 62 subjects in the public MASS-SS3 dataset using 31-fold leave-two-subject-out cross-validation, the mixed-precision approach with hybrid quantization maintains 5-class accuracy within 0.15% of the floating-point baseline when optimized for general sleep staging and N3 sensitivity within 0.51% when optimized for deep-sleep detection. The developed techniques are broadly applicable to EEG-based DL workloads.

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