Blinded sample size re-estimation aims to mitigate uncertainty in nuisance parameters at the design stage while preserving the integrity of the trial. It allows the required sample size to be updated without revealing treatment assignments and thereby reduces the risk of an inappropriate sample size. Although numerous procedures have been proposed for different outcome types, a unified framework is still lacking. We therefore develop a general framework for blinded sample size re-estimation based on nuisance parameters. Within this general framework, we develop robust methods to reduce the influence of extreme observations. The proposed framework combines asymptotically linear estimators for the parameter of interest with robust Z-estimators for nuisance parameters, thereby unifying a broad class of existing procedures through different choices of estimating functions. We also propose a general principle for constructing nuisance parameters that can be estimated from blinded data. The proposed framework is supported by asymptotic theory showing that the type I error rate converges to the nominal level under regularity conditions. Simulation studies demonstrate that the proposed method maintains reliable type I error control across a range of settings, including contaminated data and small pilot sample sizes. Compared with existing blinded and unblinded methods, the proposed framework is more flexible and less sensitive to outliers. A clinical trial application illustrates its practical utility.

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