Scientific progress is traditionally narrated through the interplay of theoretical insights and experimental findings. Yet this view of science underplays a third and central pillar of progress: the methods that underlie both conceptual advances and empirical evidence. By analysing more than 3 million articles across science published between 1980 and 2019, we find that science has undergone a fundamental structural transition. The share of papers that primarily contribute new methods-methods papers-has doubled across science over the past four decades, rising universally across disciplines and citation impact levels. Rather than a gradual evolution, this transition marks a pivotal shift beginning in the early 1990s, aligning with the computational revolution and the emergence of data-intensive science. The surge in methodological research is not confined to the most cited, elite publications; it spans the full spectrum of scientific output. These findings reveal a systemic reorientation of the scientific ecosystem where reusable methods increasingly serve as the essential infrastructure of scientific advances, challenging the traditional dichotomy of theory and experimental research. As science becomes increasingly methods-driven, our results call for rethinking how research is evaluated, funded and organised-towards better incentivising method innovations. This is especially the case as expanding AI must be effectively integrated with scientific instruments to realise its full potential.

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