In this work, a class of continuous-time autonomous dynamical systems describing many important phenomena and processes arising in real-world applications is considered. We apply the nonstandard finite difference (NSFD) methodology proposed by Mickens to design a generalized NSFD method for the dynamical system models under consideration. This method is constructed based on a novel non-local approximation for the right-side functions of the dynamical systems. It is proved by rigorous mathematical analyses that the NSFD method is dynamically consistent with respect to positivity, asymptotic stability and three classes of conservation laws, including direct conservation, generalized conservation and sub-conservation laws. Furthermore, the NSFD method is easy to be implemented and can be applied to solve a broad range of mathematical models arising in real-life. Finally, a set of numerical experiments is performed to illustrate the theoretical findings and to show advantages of the proposed NSFD method.

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