This paper investigates network-level integrated sensing and communication (ISAC) under two fundamentally different topology configurations: cell-free massive MIMO (CF-mMIMO) and multi-cell massive MIMO (MC-mMIMO). A unified OFDM-based waveform is adopted for both architectures as the key enabler for ISAC functionalities. The CF system exploits distributed access points (APs) and a scalable user-target-centric operation, whereas the MC system relies on co-located transmit-receive arrays with conventional cell-centric deployment. For both architectures, we derive a GLRT-based sensing detector and the corresponding sensing SNR expressions. We then examine a series of case studies investigating how the number of OFDM subcarriers, the transceiver allocation strategy, and the antenna/node distribution across the network affect the sensing performance. The results consistently demonstrate that CF-mMIMO provides more robust and higher sensing performance across most tested scenarios, particularly when transmit resources or antenna elements are spatially distributed. These findings highlight the inherent advantages of CF deployments for next-generation ISAC networks.

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