With advancements in learning-based policies, robots are increasingly being deployed in human-centric environments, such as manufacturing floors and homes, where safe and precise operation requires compensating for unknown loads while remaining compliant during human interactions. Reliably distinguishing between these interaction types is challenging with a single sensing modality, as force signals cannot separate payloads from human pushes, and vision is susceptible to occlusions. We propose a task-agnostic interaction estimation and adaptive control framework that addresses this challenge by fusing force history and 3D point cloud through a transformer-based classifier. Trained with modality dropout for occlusion resilience and fine-tuned from simulation to hardware, the classifier achieves 91.89% accuracy and maintains above 90% under complete occlusion of one modality. The classifier drives a system identification framework that selectively compensates for unknown payloads and a variable-impedance controller that switches between adaptive and reactive modes, while simultaneously estimating interaction forces for downstream tasks, such as human intent estimation. We validate the framework under external perturbations and unknown loads across single-arm manipulation, deployment with an imitation-learning-based policy, intent-driven target switching, and zero-shot bimanual deployment on two Franka arms lifting a box of unknown mass, demonstrating generalization to closed kinematic chains and unseen setups, enabling safe and precise deployment.

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