Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.

翻译：平台试验旨在评估多种疗法的有效性，允许试验组别晚期加入并通过共享对照组来提高效率。在分析中利用非同期对照可提升此类试验中单项治疗-对照比较的统计检验效能。我们提出R包NCC，用于采用非同期对照的平台试验设计与分析。该包支持平台试验模拟，并评估在多种情境下利用非同期对照的分析方法特性。本文阐述NCC的核心功能，并通过具体示例演示如何使用该包模拟与分析平台试验。