The Voynich Manuscript (VMS) exhibits a script of uncertain origin whose grapheme sequences have resisted linguistic analysis. We present a systematic analysis of its grapheme sequences, revealing two complementary structural layers: a character-level right-to-left optimization in word-internal sequences and a left-to-right dependency at word boundaries, a directional dissociation not observed in any of our four comparison languages (English, French, Hebrew, Arabic). We further evaluate two classes of structured generator against a four-signature joint criterion: a parametric slot-based generator and a Cardan grille implementing Rugg's (2004) gibberish hypothesis. Across their full tested parameter spaces, neither class reproduces all four signatures simultaneously. While these results do not rule out generator classes we have not tested, they provide the first quantitative benchmarks against which any future generative or cryptanalytic model of the VMS can be evaluated, and they suggest that the VMS exhibits cipher-like structural constraints that are difficult to reproduce from simple positional or frequency-based mechanisms alone.

翻译：伏尼契手稿（VMS）展示了一种来源不明的文字系统，其字位序列长期以来未能通过语言学分析获得合理解读。本文对其字位序列进行系统分析，揭示了两个互补的结构层次：词内序列中字符级别的从右向左优化，以及词边界处从左向右的依赖关系——这种方向性分离现象在四种对照语言（英语、法语、希伯来语、阿拉伯语）中均未观察到。我们进一步基于四项联合特征标准评估了两类结构化生成器：参数化槽位生成器，以及实现Rugg（2004年）胡言乱语假说的卡尔达诺格栅。在完整测试参数空间内，两类生成器均未能同时复现全部四项特征。尽管这些结果不能排除其他未测试生成器类别的可能性，但本研究为未来任何VMS生成模型或密码分析模型提供了首个定量基准，并表明VMS具有类似密码的结构约束——这类约束难以通过单纯的词位或频率机制简单再现。