Infrared small target detection (IRSTD) in high-resolution images is crucial for unmanned aerial vehicle (UAV) surveillance and UAV-based ground monitoring. However, small target size, weak features, and interference from complex dynamic backgrounds make IRSTD challenging. Existing methods incur redundant computation in non-target background regions and insufficiently exploit target context, limiting detection performance. To address these issues, we propose ECFNet, an efficient coarse-to-fine IRSTD framework with attention prior-guided knowledge distillation. In the coarse stage, we design a region binary classification network (RBCN) on grid-based multi-scale feature maps to efficiently identify target-containing context region proposals. A new denoising-assisted training strategy incorporates noisy ground-truth (GT) masks into RBCN feature maps and trains the network to reconstruct the original GT masks. This auxiliary task encourages explicit learning of target-background context to better distinguish target proposals from background regions. In the fine stage, we customize a lightweight target detector to the coarse-stage region proposals to balance accuracy and efficiency. Furthermore, we introduce a knowledge distillation strategy guided by a teacher-student cross-attention prior. This strategy directs the student to focus on critical target regions, enhancing discriminative feature representations for infrared small targets. Extensive experiments on three real infrared datasets demonstrate that ECFNet outperforms existing single-stage and two-stage approaches while maintaining high real-time processing efficiency. Code: https://github.com/IVPLabs/ECFNet.

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