Target speaker extraction (TSE) isolates a desired speaker from a multi-speaker mixture using cues that identify the target. Prior work has explored acoustic and textual cues, such as enrollment audio and different types of speaker descriptors, but typically relies on a single cue family. Yet no single cue is both broadly available and reliably discriminative. Moreover, most TSE systems adopt mask-prediction models, which are prone to audible artifacts and generalize poorly across acoustic conditions. To address these limitations, we propose PromptSep-Speaker, a generative TSE model based on latent diffusion that unifies four interchangeable cues: speaker temporal order, transcript, enrollment audio, and speaker caption. The generative formulation delivers higher separation quality and multi-modal prompting improves applicability across scenarios. To fully exploit each cue, we further introduce a frozen WavLM representation with an auxiliary alignment loss that supervises query-mixture cross-attention without extra labeling. Across four evaluation sets and a listening study, PromptSep-Speaker achieves state-of-the-art performance over TSE and universal source separation baselines, improving separation accuracy and quality across cue modalities.

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