Nonlinear dynamics arise whenever multifarious entities of a system cooperate, compete, or interfere. For example, cardiovascular system involves a great level of complexity. Multi-lead ECG signals are generated through orchestrated depolarization and repolarization of cells and manifest significant nonlinear dynamics. Nonlinear dynamical systems defy understanding based on the traditional reductionist's approach, in which one attempts to understand a system's behavior by combining all constituent parts that have been analyzed separately. In order to cope with system complexity, modern healthcare systems are investing in advanced physiological sensing and patient monitoring, thereby giving rise to big data. Realizing the full potential of big data for healthcare intelligence requires fundamentally new methodologies to harness and exploit complexity. However, available nonlinear dynamics techniques are either not concerned with healthcare analytical objectives or fail to effectively analyze big data to extract useful information for improving healthcare services. There is an urgent need to develop analytical methodologies that fully exploit the underlying nonlinear dynamics in physiological systems for advancing healthcare services with exceptional features such as personalization, responsiveness, and superior quality. This chapter presents some theoretical developments and tools to advance the applications of nonlinear dynamics principles in health care. Specifically, we focus on sensor-based characterization and modeling of nonlinear dynamics (i.e., multifractal analysis and multiscale recurrence quantification). Then, current developments and applications of these methodologies are examined for characterizing and exploiting heart rate variability and space-time ECG signals.

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