Diagnosing mobile crashes in ultra-large-scale industrial applications is a formidable challenge due to the sheer volume of code, the complexity of mixed-language environments, and the inability to reproduce failures locally. Traditional static analysis struggles with scalability, while existing LLM-based agents often rely on reproducible environments unavailable in post-mortem scenarios. We present Holmes, a multi-agent system that automates root cause analysis by synthesizing multimodal runtime signals--stack traces, logs, and thread states--to reconstruct failure contexts without reproduction. Holmes introduces a hierarchical Retrieve-Explore-Reason architecture that leverages low-level artifacts (e.g., registers, assembly) to bridge the semantic gap between open-source business logic and closed-source system frameworks. By dynamically compressing the search space using runtime clues, Holmes precisely navigates 70-million-line codebases to identify non-local defects. Evaluated on real-world crashes from WeChat, Holmes achieves 87.6% accuracy in function-level fault localization and reduces average investigation time by over 98% (to ~77 seconds), demonstrating its effectiveness in transforming labor-intensive debugging into an efficient verification workflow.

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