Quantized Neural Networks~(QNN) with low-bitwidth data have proven promising in efficient storage and computation on edge devices. To mitigate accuracy degradation while maximizing speedup, layer-wise mixed-precision quantization~(MPQ) becomes a popular solution. However, existing algorithms for exploring MPQ schemes are limited in flexibility and efficiency. Comprehending the complex impacts of different MPQ schemes on post-training quantization and quantization-aware training results is a challenge for conventional methods. Furthermore, an end-to-end framework for the optimization and deployment of MPQ models is missing in existing work. To address these challenges, we propose the MiCo framework, a holistic MPQ exploration and deployment framework for edge AI applications. The framework adopts a novel optimization algorithm to search for accuracy-optimal quantization configurations under strict latency constraints. We further extended the framework to MiCoPro, which introduces a robust Hardware-Aware Proxy (HAP) model to enhance prediction accuracy and hardware versatility. By leveraging target-specific latency modeling, MiCoPro enables rapid exploration and direct deployment from PyTorch models to bare-metal C code. We demonstrate the versatility of our framework on both the BitFusion accelerator and SIMD-extended RISC-V processors, achieving up to 40\% of latency reduction with less than 3\% of accuracy drop.

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