This work addresses the patient-specific characterisation of the morphology and pathologies of muscle-skeletal districts (e.g., wrist, spine) to support diagnostic activities and follow-up exams through the integration of morphological and tissue information. We propose different methods for the integration of morphological information, retrieved from the geometrical analysis of 3D surface models, with tissue information extracted from volume images. For the qualitative and quantitative validation, we will discuss the localisation of bone erosion sites on the wrists to monitor rheumatic diseases and the characterisation of the three functional regions of the spinal vertebrae to study the presence of osteoporotic fractures. The proposed approach supports the quantitative and visual evaluation of possible damages, surgery planning, and early diagnosis or follow-up studies. Finally, our analysis is general enough to be applied to different districts.

翻译：本研究针对患者特异性的肌肉骨骼区域（如腕部、脊柱）的形态及病理特征，通过整合形态学与组织信息支持诊断活动及随访检查。我们提出了多种方法，将基于三维表面模型几何分析获取的形态信息与从体积图像中提取的组织信息相结合。为进行定性与定量验证，将讨论如何定位腕部骨侵蚀部位以监测风湿性疾病，以及如何表征脊柱椎体的三个功能区域以研究骨质疏松性骨折的存在。所提出的方法可支持潜在损伤的定量与视觉评估、手术规划，以及早期诊断或随访研究。最后，我们的分析具有足够普适性，可适用于不同解剖区域。