Precise multimodal retinal image rigid registration (MRIRG) is essential for aligning cross-modal vessel structures, offering critical guidance for ophthalmic surgery. Despite its significance, the advancement of MRIRG is hindered by the lack of publicly available multimodal retinal image rigid registration datasets spanning various ophthalmic surgery phases (e.g., preoperative, intraoperative, and postoperative). To address this issue, we introduce the MICRO dataset, a large-scale MRIRG benchmark, comprising 1,365 cross-modal retinal image pairs with standardized annotations across all ophthalmic surgery phases. Moreover, existing deep registration methods achieve competitive MRIRG results via a two-step segmentation-then-detection framework, but segmentation quality heavily constrains their performance. We argue that this dependency stems from an implicit need for keypoint topology constraints, which have not been exploited for MRIRG through a one-step registration framework. Inspired by the above analysis, we propose a novel One-step Frequency-Structure Similarity Registration (OFS2Reg) learning framework for MRIRG that leverages the potential of cross-modal vessel structure similarities to construct keypoint topology constraints under a shared detection network. To be specific, OFS2Reg applies a well-designed frequency-guided structure preservation descriptor to construct coarse keypoint topology constraints in descriptors by highlighting significant vessel structures. Additionally, we develop a new cross-modal vessel structure similarity learning method that refines cross-modal keypoint topology constraints to precisely align pixel-level cross-modal vessel structures by leveraging cross-modal vessel structure similarity priors.

翻译：暂无翻译