Multi-agent systems can differ under identical agents and communication budgets when they support different forms of joint interaction. We introduce Topological Sheaves of Irreducibility (TSI), a sheaf-theoretic framework separating task-level compatibility obstructions from system capability. A task is represented by an interaction complex $K$ and a capacity sheaf $\mathcal{F}$; nonzero $H^n(K;\mathcal{F})$ defines a structural signature, while registered interventions test capability. For cocycle data, cochain realization is solvable exactly when the represented cohomology class vanishes. Examples show that the signature is sheaf-relative, and the degree-1 reduction yields cycle-space witnesses and observation requirements. We evaluate two finite one-round models. Across 15,625 degree-1 inputs, an all-agent additive primitive solves decision and repair exactly; the optimal pairwise system reaches 88.80% on decision, one input above the 88.79% majority-class baseline, and 26.63% on repair. On a degree-2 tetrahedral-boundary task over 531,441 inputs, the same-2-skeleton system retains all four three-agent primitives yet matches the pairwise-only optimum throughout the registered separation window, whereas adding the class-filling four-agent primitive makes both tasks exact. Status-preserving robustness checks retain exact performance but are not cost-matched to the class-restoring ablation. Conditional on the registered primitives and cost models, TSI provides task-relative, falsifiable tests of higher-order interaction.

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