Inter-symbol interference (ISI) with heteroscedastic, or state-dependent, noise is a defining feature of molecular communication via diffusion (MCvD). However, such noise variance dependency across ISI states has not been systematically considered in prior detector designs. This letter introduces two decoding mechanisms, Belief-Adaptive Maximum A Posteriori (BA-MAP) and Soft BA-MAP, that explicitly incorporate state-dependent means and variances of the molecular count channel. The BA-MAP method derives per-symbol adaptive MAP thresholds based on the receiver's current state beliefs, whereas the Soft BA-MAP approach computes mixture log-likelihood ratios by weighting all possible ISI states. Simulation and information-theoretic analyses confirm that the proposed detectors outperform conventional equalization and fixed-threshold methods, achieving up to 100% throughput improvement under realistic MCvD settings.

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