Referring expression segmentation (RES) aims to localize targets at the pixel level guided by human instructions. However, current models predominantly follow a text-centric paradigm that treats discrete text as the primary interaction medium for these human instructions. This assumption is especially limiting in unmanned aerial vehicle (UAV) applications, where rapid response, hands-free operation, and natural communication are often critical. In this paper, we reconstruct UAV referring expression segmentation through an audio-centric perspective. Grounded in information theory, we demonstrate that raw audio provides a higher upper bound for extracting rich semantic features than transcribed text. To achieve this, we construct an audio-driven UAV referring expression segmentation benchmark named Aerial-AudioRES by augmenting VisDrone with synthesized speech, forming "audio-text-image-mask" quadruples. Specifically, we employ an ambiguity filtering mechanism to ensure referential uniqueness, and incorporate eight distinct timbres alongside 4 realistic noises to simulate authentic environments. To drive the paradigm shift from text-centric to audio-centric, we propose the end-to-end Audio-centric Referring Expression Segmentation Network (ARES-Net). Distinct from discrete text-visual matching, our approach learns to establish a direct soft alignment between continuous acoustic manifolds and multi-scale visual representations. Comprehensive experiments show that our method obtains a peak accuracy of 64.23% in oIoU and demonstrates robust generalization on a collected real-human test set. Furthermore, it significantly reduces total interaction latency to one-third of the text-based method. Our code is available at https://github.com/LemonGauss/ARES-Net.

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