Diffusion models have recently emerged as a powerful paradigm for generating 3D molecules. Despite showing remarkable promise, they learn atomic distributions implicitly from data, without explicitly encoding physicochemical rules into their generative dynamics. Consequently, generated samples can be statistically plausible yet chemically invalid. To address this problem, we propose Sequential Neuro-Symbolic Constrained Diffusion (SensDiff), a framework that integrates symbolic rules into generative modeling, enabling the model to internalize scientific priors during training. Central to SensDiff is the observation that the diffusion trajectory of 3D molecule generation exhibits a coarse-to-fine evolution: valid molecules arise by first mitigating macroscopic geometric conflicts and then refining structures toward microscopic chemical consistency through iterative denoising. Accordingly, SensDiff mirrors this dynamic by sequentially enforcing constraints with adaptive weighting during training, progressively steering generation toward valid molecular geometries. Moreover, SensDiff translates domain knowledge into interpretable generative controls, grounding opaque neural denoising in scientific principles. Experiments on molecular benchmarks and real-world constrained generation tasks confirm that SensDiff consistently improves chemical validity while adhering to physicochemical rules and user-specified targets. The code is publicly available at https://github.com/WanyuGroup/NeurIPS2026_SensDiff.

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