The use of intracytoplasmic sperm injection (ICSI), an assisted reproductive technique (ART), is increasing widely. ICSI is currently performed by specially skilled embryologists. However, with the increasing demand for ART, the shortage of skilled embryologists has become a problem. Therefore, we propose an immersive micromanipulation system that requires no special skills for efficient and accurate micromanipulation. Our proposed system is composed of a real-time three-dimensional (3D) imaging microscope and 3D operation interfaces. The 3D operation interfaces are stationary pen-type or wearable glove-type interfaces. In this system, an operator wearing a head-mounted display (HMD) and using 3D operation interfaces is immersed in a virtual micromanipulation space. The operator can move the pipettes by 3D operation interface and freely change the viewpoint. We verified that the proposed system improves the speed and accuracy of operating a pipette through two types of experiments with subjects.

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