Debiased machine learning estimators for smooth functionals in nonparametric models can exhibit substantial variability and instability, often leading practitioners to instead rely on parametric or semiparametric working models. Such models, however, may be misspecified and can therefore introduce bias. We study how data-driven model selection can be combined with debiased machine learning to construct estimators that adapt to structure in the data-generating distribution. To this end, we propose Adaptive Debiased Machine Learning (ADML), a nonparametric framework for constructing superefficient estimators of pathwise differentiable parameters. The framework unifies a broad class of previously proposed adaptive estimators, including methods based on variable selection, learned feature representations, and collaborative targeted learning. It requires only high-level conditions and approximate validity of the selection procedure, which are implied by lower-level conditions already assumed in important settings, including sieve-based selection, sparsity-based methods such as the Lasso, and data-adaptive feature representations. We show that ADML estimators yield regular and efficient root-\(n\) inference for an oracle projection parameter induced by a data-adaptive oracle submodel. This oracle parameter coincides with the target parameter at the true distribution but typically has a smaller efficiency bound, thereby yielding superefficiency for the target parameter. As a practical illustration, we introduce a broad class of automatic ADML estimators for continuous linear functionals of the outcome regression, in which model selection is performed directly on the regression itself. Motivated by overlap challenges in causal inference, we develop new superefficient plug-in estimators for the average treatment effect based on calibration in semiparametric regression models.

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