The advent of quantum computing poses a critical threat to RSA cryptography, as Shor's algorithm can factor integers in polynomial time. While post-quantum cryptography standards offer long-term solutions, their deployment faces significant compatibility and infrastructure challenges. This paper proposes the Constrained Rényi Entropy Optimization (CREO) framework, a mathematical approach to potentially enhance the quantum resistance of RSA while maintaining full backward compatibility. By constraining the proximity of RSA primes ($|p-q| < γ\sqrt{pq}$), CREO reduces the distinguishability of quantum states in Shor's algorithm, as quantified by Rényi entropy. Our analysis demonstrates that for a $k$-bit modulus with $γ= k^{-1/2+ε}$, the number of quantum measurements required for reliable period extraction scales as $Ω(k^{2+ε})$, compared to $\mathcal{O}(k^3)$ for standard RSA under idealized assumptions. This represents a systematic increase in quantum resource requirements. The framework is supported by constructive existence proofs for such primes using prime gap theorems and establishes conceptual security connections to lattice-based problems. CREO provides a new research direction for exploring backward-compatible cryptographic enhancements during the extended transition to post-quantum standards, offering a mathematically grounded pathway to harden widely deployed RSA infrastructure without requiring immediate protocol or infrastructure replacement.

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