This paper proposes new methodologies for conducting practical differentially private (DP) estimation and inference in high-dimensional linear regression. We first introduce a DP Bayesian Information Criterion (DP-BIC) for selecting the unknown sparsity parameter in differentially private sparse linear regression (DP-SLR), eliminating the need for prior knowledge of model sparsity, which is a requisite in the existing literature. Next, we develop the DP debiased algorithm that enables privacy-preserving inference on a particular subset of regression parameters. Our proposed method enables privacy-preserving inference on the regression parameters by leveraging the inherent sparsity of high-dimensional linear regression models. Additionally, we address private feature selection by considering multiple testing in high-dimensional linear regression by introducing a DP multiple testing procedure that controls the false discovery rate (FDR). This allows for accurate and privacy-preserving identification of significant predictors in the regression model. Through extensive simulations and real data analyses, we demonstrate the effectiveness of our proposed methods in conducting inference for high-dimensional linear models while safeguarding privacy and controlling the FDR.

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