Accurate through-thickness measurement of subsurface delamination depth in Carbon Fiber Reinforced Polymer (CFRP) is important for structural assessment because defect location determines affected load-bearing layers. Optical pulsed thermography (OPT) provides a two-dimensional thermal video rather than volumetric measurements, so depth must be inferred from temporal heat-diffusion responses. A challenge is spatial dataset bias: when calibration defects follow regular grids, regression models may memorize their geometry instead of learning physical relationship between thermal decay and depth. This work introduces a spatio-temporal decoupling architecture that separates spatial defect localization from temporal depth measurement. Defect regions are first localized using segmentation methods, after which thermal responses are spatially averaged and converted into sixteen physics-informed temporal, energy, statistical, and geometric features. These features expose the one-dimensional heat-conduction relationship while withholding pixel coordinates from the depth model. Four regression models are evaluated using specimen-level cross-validation: Random Forest (RF), Gradient Boosting Machine (GBM), Advanced Multi-Layer Perceptron (Adv-MLP), and XGBoost. Unregularized trees and over-parameterized Adv-MLP exhibit calibration collapse under geometric shifts, with errors exceeding 0.5 mm. In contrast, regularized XGBoost with L1/L2 penalties and column sampling maintains cross-specimen calibration, achieving a mean absolute error (MAE) of 0.056 mm and root mean square error (RMSE) of 0.085 mm. Predicted depths are merged with masks to generate Delaunay-triangulated three-dimensional defect models in three to five seconds per specimen. Results show that mathematical regularization and spatio-temporal decoupling reduce spatial memorization in thermal-video depth regression.

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