Modern supply chain operations can require coordinating replenishment across thousands of heterogeneous items under correlated stochastic demand, heterogeneous lead times, and shared fixed ordering costs, yielding observation spaces exceeding $10^4$ dimensions. At this scale, rolling-horizon stochastic mixed-integer linear programs (MILPs) become prohibitively slow, while standard reinforcement learning (RL) methods face increasingly challenging credit assignment in high-dimensional action spaces. We introduce OR-Transformer, a deep reinforcement learning framework for joint replenishment under stochastic demand, with an item-permutation-equivariant Transformer architecture and pathwise-gradient training through the inventory dynamics. Across problem sizes up to 1,024 inventory items, OR-Transformer increasingly outperforms learning-based and rolling-horizon MILP baselines as scale grows. It also reduces online decision-making time by over 4 million times relative to MILP solvers, enabling real-time, large-scale deep RL in supply chain operations.

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