Semantic segmentation decomposes an image into distinct mask regions corresponding to different object categories, such as people, cars, signs or buildings. Advances in machine learning (ML) have shifted this task away from traditional rule-based heuristics such as edge detection, towards deep neural networks (DNN) that learn to classify pixels directly. However, semantic segmentation DNNs crucially depend on expertly designed mask targets to learn from, and imperfect or misaligned masks can interfere with a model's ability to learn effectively. This paper presents a comparative study of segmentation architectures, ranging from convolutional backbones to vision transformers, applied to the B.O.V.I.D. dataset, a corpus of high-resolution bovid dental photographs paired with hand-made segmentation masks not originally designed for ML-based training. We evaluate a range of preprocessing and alignment techniques to mitigate the resulting label imperfections. We find that while these preprocessing choices have limited effect on quantitative metrics such as Dice score and mIoU, their qualitative impact on predicted masks is substantial.

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