Ensuring operational safety in threat-prone environments remains a critical challenge for multi-UAV networks serving as aerial base stations. This paper proposes an efficient framework to maximize global energy efficiency (EE) while promoting safe operation through threat-aware clustering and reward-based safety enforcement. The proposed framework is executed in three steps. First, a threat-aware K-means (TAKM) algorithm determines the minimum required UAVs and computes safe initial placements. Second, an optimal matching stage assigns physical UAVs to these centroids to minimize energy expenditure. Third, a threat-aware multi-agent twin delayed deep deterministic policy gradient (MATD3) algorithm dynamically optimizes trajectories, power, and user associations. Simulation results show that the proposed framework achieves zero observed safety violations in the considered scenarios while achieving superior EE and faster convergence than other learning methods and non-clustering baselines. Compared to heuristic optimization, the proposed framework outperforms the greedy particle swarm optimization (GPSO) and achieves performance comparable to that of the optimized PSO (OPSO), while incurring significantly lower online deployment computational complexity. Furthermore, the proposed framework demonstrates effective generalization to unseen user distributions, large UAV fleets, and different threat geometries, while maintaining zero safety violations.

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