Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery system capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, enabling effective hosting of therapeutics despite the integration complexity of its components, offering a promising solution for precise targeted drug delivery.

翻译：系统性给药常导致脱靶效应，从而限制了先进疗法的疗效。靶向给药方法能在提高病灶局部药物浓度的同时，最大限度地减少全身药物暴露。我们提出了一种磁引导微型机器人给药系统，能够在生理条件下实现精确导航。该平台集成了临床电磁导航系统、定制设计的释放导管以及用于精确治疗给药的可溶解胶囊。体外实验表明，该系统能在人体血管模型中实现精确导航；体内实验则证实了其在荧光透视下的可追踪性，并在大型动物模型中成功实现了导航。该微型机器人平衡了磁性材料浓度、造影剂负载与治疗药物容量，尽管其组件集成复杂，仍能有效承载治疗药物，为精确靶向给药提供了一种前景广阔的解决方案。