Computed tomography (CT) is routinely used for three-dimensional non-invasive imaging. Numerous data-driven image denoising algorithms were proposed to restore image quality in low-dose acquisitions. However, considerably less research investigates methods already intervening in the raw detector data due to limited access to suitable projection data or correct reconstruction algorithms. In this work, we present an end-to-end trainable CT reconstruction pipeline that contains denoising operators in both the projection and the image domain and that are optimized simultaneously without requiring ground-truth high-dose CT data. Our experiments demonstrate that including an additional projection denoising operator improved the overall denoising performance by 82.4-94.1%/12.5-41.7% (PSNR/SSIM) on abdomen CT and 1.5-2.9%/0.4-0.5% (PSNR/SSIM) on XRM data relative to the low-dose baseline. We make our entire helical CT reconstruction framework publicly available that contains a raw projection rebinning step to render helical projection data suitable for differentiable fan-beam reconstruction operators and end-to-end learning.

翻译：在这项工作中,我们提出了一个终端到终端可培训的CT重建管道,其中包含了投影和图像领域的拆卸操作员,并且同时优化,而不需要地面真实的高剂量CT数据。我们的实验表明,包括一个额外的投影拆卸操作员将ABOMEN CT的总体拆卸性能提高了82.4-94.1%/12.5-41.7%(PSNR/SSIM)和XRM 数据相对于低剂量基准的1.5-2.9%/0.4%/0.5%(PSNR/SSIM)。