Digital innovations have strongly improved ship capabilities, including command, control & communication, navigation and combat management. In the wake of digitisation and geopolitical stress, resilience against cyber-attacks has become a key challenge. Autonomous Cyber Resilience (ACR) methods, inspired by features of the human immune system, provide a promising perspective. Proofs of concept of autonomous self-healing and self-protecting software have been realised in cloud environments using containerisation, monitoring and deployment technology. However, developing a suitable "cyber immune system" for more complex digital systems is still an intricate challenge. In this paper, we share insights on how ACR methods can be combined with resilience mechanisms present in critical naval and aeronautical manoeuvring systems. Using TNO's "OpPic" application, we show how TNO's Self-Healing for Cyber Security software can provide autonomous mission- and threat-adaptive resilience. On this basis, six guidelines for the design of autonomous cyber resilient systems are derived. The ultimate goal is to enable operators to oversee and control their system's "cyber immune response", to be able to continuously adapt to evolving threats and mission priorities.

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