A common experimental research design is one in which individuals are randomly allocated into groups that then interact under different group-level treatment conditions. We develop design-based inference for such "group interaction" experiments, covering scenarios in which groups are either fixed or randomly formed and in which potential outcomes are either fixed relative to others' group assignments or subject to interference. For each scenario, we characterize the causal estimand that the design targets and the inferential strategy appropriate to it. Working in a sparse-sampling asymptotic regime, we show that cluster-robust inference remains consistent and accounts for dependencies from various sources when interference is present, delivering valid inference on marginalized exposure effects. When interference is absent and groups are formed randomly, the design reduces to an individually randomized experiment, and individual-level heteroskedasticity-robust inference suffices for the average treatment effect. Our results on the asymptotic distribution of commonly used estimators rely on a novel coupling strategy that may be useful for design-based inference in other complex experiments.

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