Robust regression methods, particularly MM-estimators, are essential for analyzing datasets where heavy-tailed noise or high-leverage outliers may be present. Algorithms to compute these estimators are iterative and rely on having a good initial point. A widely-used probabilistic approach to obtaining an initial regression estimator that is not affected by outliers consists of fitting linear regression models to many random subsets of the training data. Unfortunately, the number of subsets that need to be considered in order to have a high probability of finding one that is clean of outliers grows exponentially with the number of predictors. This renders the approach unfeasible for models with a moderate to large numbers of variables. Alternative non-stochastic strategies that have been proposed recently also fail to scale well when the number of parameters and observations are large. To overcome this problem, we propose a highly scalable algorithm based on block-coordinate descent. Our Robust Orthogonal Block Updates (ROBU) algorithm uses lower-dimensional blocks of explanatory variables, which require much fewer sub-samples to find a good initial point with high probability. Extensive simulations and a proteogenomics data application illustrate the robustness properties of the estimators computed with ROBU and demonstrate that they compare favourably to those calculated with existing algorithms.

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