As quantum computing resources remain scarce and error rates high, minimizing the resource consumption of quantum circuits is essential for achieving practical quantum advantage. Here we consider the natural problem of, given a circuit $C$, computing a circuit $C'$ that behaves equivalently on a desired subspace, and that minimizes a quantum resource type, expressed as the count or depth of (i) all gates, or (ii) non-Clifford gates, or (iii) superposition gates, or (iv) entanglement gates. We show that, when $C$ is expressed over any gate-set that can implement the H and TOF gates exactly, a standard property of approximately universal gate-sets, each of the above optimization problems is hard for co-NQP, and hence outside the Polynomial Hierarchy, unless the Polynomial Hierarchy collapses. This complements a recent result of Van de Wetering and Amy (arXiv, 2023) which establishes an NP-hardness lower bound when equivalence is over the full state space, and tightens the gap to the corresponding $\text{NP}^\text{NQP}$ upper bound known for cases (i)-(iii) over Clifford+T and (i)-(iv) over H+TOF circuits. Our result also generalizes a result by Tanaka (Int. J. Quantum Inf., 2010) to other gate-sets and quantum resources.

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