A new method for including systematic errors in the regression with Poisson data is reviewed in this contribution, with emphasis on applications to astronomical spectra. The method consists of generalizing the usual Poisson log-likelihood, known as the Cash statistic $C_{min}$, and its associated likelihood-ratio statistic $ΔC$, to include the presence of systematic sources of uncertainty. Advantages of this new method include its modeling simplicity and its ability to assess both the level of systematics and the goodness of fit at the same time, including for a nested model component.

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