NVIDIA's CUDA Tile (CuTile) introduces a Python-based, tile-centric abstraction for GPU kernel development that aims to simplify programming while retaining Tensor Core and Tensor Memory Accelerator (TMA) efficiency on modern GPUs. We present the first independent, cross-architecture evaluation of CuTile against established approaches such as cuBLAS, Triton, WMMA, and raw SIMT on three NVIDIA GPUs spanning Hopper and Blackwell: H100 NVL, B200, and RTX PRO 6000 Blackwell Server Edition. We benchmark representative AI workloads, including GEMM, fused multi-head attention, and end-to-end LLM inference in BF16/FP16 precision, to assess both performance and portability. Our results show that CuTile effectiveness is strongly workload- and architecture-dependent. On datacenter-class Blackwell (B200), CuTile achieves up to 1007 TFLOP/s for fused attention, outperforming FlashAttention-2 by 2.5x while requiring only 60 lines of Python kernel code. For GEMM, CuTile reaches 52-79% of cuBLAS performance in 22 lines of code (versus 123 for WMMA), making it a practical replacement for hand-written CUDA kernels but not yet for vendor-optimized libraries. However, the same CuTile attention kernel achieves only 53% of FlashAttention-2 throughput on RTX PRO 6000 (sm_120), exposing significant cross-architecture optimization gaps. In contrast, Triton sustains 62-101% of cuBLAS performance across all tested platforms without architecture-specific tuning, demonstrating substantially stronger portability.

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