Ptychography is a powerful lensless imaging technique capable of approaching the diffraction limit, yet its performance is increasingly constrained by non-ideal detection hardware. In photon-limited measurements, weak high-frequency diffraction signals often overlap with spatially heterogeneous detector noise, whereas most reconstruction algorithms still treat the detector as an ideal measurement plane. Here, we introduce detector-informed measurement consistency into ptychographic reconstruction. By calibrating the pixelwise sensor response, the method construct a spatially resolved confidence map and embed it into the iterative amplitude constraint, allowing unreliable detector residuals to be down-weighted while preserving physically meaningful diffraction information. Experiments across transmission, reflection, and weak biological phase imaging show improved diffraction-data quality, an approximately twofold signal-to-noise ratio (SNR) enhancement, and reconstruction approaching the Rayleigh limit with a measured (k)-factor of about 0.65. Compared with previous advanced denoising methods, the proposed framework achieves a better balance between suppressing detector-induced background and preserving structural diffraction information. These results show that detector reliability can be used as an in-loop physical constraint to extend the performance of ptychographic imaging with imperfect sensors.

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