AI Scientific Assistant Core (AISAC) is a transparent, modular multi-agent runtime developed at Argonne National Laboratory to support long-horizon, evidence-grounded scientific reasoning. Rather than proposing new agent algorithms or claiming autonomous scientific discovery, AISAC contributes a governed execution substrate that operationalizes key requirements for deploying agentic AI in scientific practice, including explicit role semantics, budgeted context management, traceable execution, and reproducible interaction with tools and knowledge. AISAC enforces four structural guarantees for scientific reasoning: (1) declarative agent registration with runtime-enforced role semantics and automatic system prompt generation; (2) budgeted orchestration via explicit per-turn context and delegation depth limits; (3) role-aligned memory access across episodic, dialogue, and evidence layers; and (4) trace-driven transparency through persistent execution records and a live event-stream interface. These guarantees are implemented through hybrid persistent memory (SQLite and dual FAISS indices), governed retrieval with agent-scoped RAG, structured tool execution with schema validation, and a configuration-driven bootstrap mechanism that enables project specific extension without modifying the shared core. AISAC is currently deployed across multiple scientific workflows at Argonne, including combustion science, materials research, and energy process safety, demonstrating its use as a reusable substrate for domain-specialized AI scientific assistants.

翻译：AI科学助手核心（AISAC）是阿贡国家实验室开发的一个透明、模块化的多智能体运行时系统，旨在支持长视野、证据驱动的科学推理。AISAC并非提出新的智能体算法或宣称实现自主科学发现，而是贡献了一个受治理的执行基座，将部署智能体AI于科学实践中的关键需求操作化，包括显式的角色语义、预算化的上下文管理、可追溯的执行以及与工具和知识的可复现交互。AISAC为科学推理强制执行四项结构保证：（1）通过运行时强制的角色语义和自动系统提示生成进行声明式智能体注册；（2）通过显式的每轮上下文和委托深度限制实现预算化编排；（3）在情景、对话和证据层之间实现角色对齐的记忆访问；（4）通过持久执行记录和实时事件流接口实现追踪驱动的透明度。这些保证通过混合持久记忆（SQLite和双FAISS索引）、具有智能体范围RAG的受治理检索、带有模式验证的结构化工具执行，以及一个配置驱动的引导机制来实现，该机制支持项目特定扩展而无需修改共享核心。AISAC目前已在阿贡的多个科学工作流中部署，包括燃烧科学、材料研究和能源过程安全，展示了其作为领域专用AI科学助手的可复用基座的应用价值。