Multi-objective optimisation using BRIGHT has proven insightful and effective in prostate cancer brachytherapy treatment planning. BRachytherapy via artificially Intelligent GOMEA-Heuristic based Treatment planning (BRIGHT) generates multiple treatment plans, each with a different trade-off between tumour coverage and organs-at-risk sparing. BRIGHT was recently extended to cervical cancer brachytherapy. In this study, we present a novel, custom-developed graphical user interface (GUI) that enables plan navigation, pairwise comparisons, dose distribution visualisation, and possibility for adjustments - essential for efficient clinical use of BRIGHT. End-user validation of BRIGHT with the dedicated GUI was conducted for cervical cancer brachytherapy by emulating clinical practice in ten previously treated patients. A multidisciplinary brachytherapy team used BRIGHT to create new treatment plans. GUI usability was assessed using the System Usability Scale (SUS). BRIGHT plan quality was compared to clinical practice via blinded one-on-one comparisons. The GUI offered helpful features for plan navigation and evaluation, giving users quick insight into whether planning aims are achievable and what treatment options are available. The overall SUS score was 83.3, indicating an 'excellent' system. BRIGHT outperformed clinical practice in five out of ten patients regarding the coverage-sparing trade-off and performed equally well in the remaining five. The BRIGHT plan was preferred over the clinical plan in eight out of ten patients, four of which showed clinically relevant differences. The clinical plan was preferred in two patients, neither with clinically relevant differences. In conclusion, BRIGHT, with its dedicated GUI, is a clinically viable and user-friendly tool for treatment planning in cervical cancer brachytherapy.

翻译：使用BRIGHT进行多目标优化在前列腺癌近距离放疗计划制定中已被证明具有洞察力和有效性。基于人工智慧GOMEA启发式算法的近距离放疗计划系统（BRIGHT）可生成多个治疗计划，每个计划在肿瘤覆盖与危及器官保护之间具有不同的权衡。BRIGHT近期已扩展应用于宫颈癌近距离放疗。本研究提出了一种新颖的定制图形用户界面（GUI），该界面支持计划导航、成对比较、剂量分布可视化以及调整可能性——这些功能对于BRIGHT在临床中的高效使用至关重要。通过模拟十例既往已治疗患者的临床实践，我们使用专用GUI对BRIGHT在宫颈癌近距离放疗中的应用进行了终端用户验证。一个多学科近距离放疗团队使用BRIGHT制定了新的治疗计划。采用系统可用性量表（SUS）评估了GUI的可用性。通过盲法一对一比较，将BRIGHT计划质量与临床实践进行了对比。该GUI为计划导航和评估提供了实用功能，使用户能快速了解计划目标是否可实现以及存在哪些治疗选择。总体SUS得分为83.3分，表明该系统“优秀”。在覆盖与保护的权衡方面，BRIGHT在十例患者中有五例优于临床实践，其余五例表现相当。在十例患者中，有八例更倾向于选择BRIGHT计划，其中四例显示出具有临床相关性的差异。两例患者更倾向于临床计划，但均未显示临床相关性差异。综上所述，配备专用GUI的BRIGHT系统是宫颈癌近距离放疗计划制定中临床可行且用户友好的工具。