This study explores the effects of electric charge on the dynamics of drug transport and absorption in subcutaneous injections of monoclonal antibodies (mAbs). We develop a novel mathematical and computational model, based on the Nernst-Planck equations and porous media flow theory, to investigate the complex interactions between mAbs and charged species in subcutaneous tissue. The model enables us to study short-term transport dynamics and long-term binding and absorption for two mAbs with different electric properties. We examine the influence of buffer pH, body mass index, injection depth, and formulation concentration on drug distribution and compare our numerical results with experimental data from the literature.

翻译：本研究探讨了电荷对皮下注射单克隆抗体（mAbs）药物转运与吸收动力学的影响。我们基于能斯特-普朗克方程和多孔介质流动理论，建立了一个新颖的数学与计算模型，用于研究皮下组织中单克隆抗体与带电物质之间的复杂相互作用。该模型使我们能够研究两种不同电学特性单克隆抗体的短期转运动力学及长期结合与吸收过程。我们考察了缓冲液pH值、身体质量指数、注射深度和制剂浓度对药物分布的影响，并将数值模拟结果与文献中的实验数据进行了对比。